Project: Studying virus-host interactions using complex in vitro respiratory culture systems
Subbarao Group
This project will utilise several respiratory models established in the lab including air-liquid interface cultures modeling the nose and upper respiratory tract to study coronaviruses. These systems will be used to study virus replication, entry, host response and antiviral efficacy. In addition, this project will establish a new in vitro model using precision cut lungs slices from mice to study host responses to coronaviruses.
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Subbarao Group
4 vacancies
Research in the Subbarao laboratory focuses on respiratory viral diseases of global importance including pandemic and seasonal influenza and coronaviruses including SARS-CoV-2 (COVID-19) and human coronaviruses. We study virus biology and pathogenesis, airborne spread of respiratory viruses, immune responses to infection and vaccination, and antiviral drugs. We use state of the art techniques in virology, molecular biology and immunology, including reverse genetics, infection of stem cell derived tissues and studies in animal models.
Subbarao Group Current Projects
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Defining the placental response to SARS-CoV-2 infection
PhD/MPhil, Master of Biomedical Science
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Studying virus-host interactions using complex in vitro respiratory culture systems
PhD/MPhil, Master of Biomedical Science, Honours
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Defining the role of secreted mucins in seasonal human coronavirus infection
Master of Biomedical Science, Honours
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Understanding how SARS-CoV-2 Spike antigen leads to myocarditis
Master of Biomedical Science, Honours
Research degrees at the Doherty Institute are administered by the University of Melbourne.