Research
Virology
- Evaluation of new antiviral drugs for hepatitis B (HBV) and hepatitis C (HCV) infection
- Study of HIV and HBV co-infection and HIV and HCV co-infection
- Studies of antiviral drug resistance
- Bioinformatic analysis/data mining of viral genomes
- Epitope mapping
- Antiviral drug resistance screening
- Vaccine efficacy (neutralisation assays)
- Evaluation of new molecular technologies
- Evaluation of diagnostic virology and microbiology laboratory platforms
- Epidemiological study design and analysis
- Estimation of disease control measure effectiveness
Microbiology
- Genomics
- Short read (Illumina) and long read (PacBio) sequencing
- Bioinformatics
- Maintenance of reference collections
- Doherty Applied Microbial Genomics
CONTACT
Microbiological Diagnostic Unit Public Health Laboratory
T:+61 3 8344 5701
Advanced immune profiling
- Advanced animal models for HIV and influenza vaccine and pathogenesis studies
- High level immunologic monitoring of human and primate immunology studies
- Analyses of a range of functional anti-viral antibody responses
- Interactions of nanoparticles with human immune cells
- Biobanks of HIV, SIV and Influenza samples from human and primate animal model studies
HIV clinical research services
- Establishing and maintaining prospective clinical cohorts
- Biobanking HIV-infected and HIV-HBV co-infected individuals
- Early phase clinical trials
- Viral isolation from patient samples in patient samples including blood and tissue
- Quantification of HIV viral RNA and DNA
- In vitro HIV latency model
CONTACT
Ajantha Rhodes (Lewin/Cameron Laboratory)
T:+61 3 8344 3611
E:ajantha.solomon@unimelb.edu.au
Immuno-evaluation of vaccine and immunotherapy clinical trials
- Ex vivo and in vitro evaluation of naïve, effector and memory antigen-specific cells
- Tetramer detection of naïve, effector and memory antigen-specific CD8+ T cells (viral and cancer)
- Functional flow cytometry analysis of intracellular IFN-gamma, TNF-alpha, MIP-1beta, granzyme B and CD107a
- Optimised custom-designed multi-colour (>15 colours per sample) flow cytometry phenotypic analysis of innate and adaptive immune responses
- Induction of plasmablasts and follicular T cells following vaccination/therapy
- Serum levels of cytokines/chemokines by flow cytometry (>18 parameters)
- Generation of T cell lines in vitro
- Single cell RT-PCR analysis of T cell receptors for CD8+, CD4+ and gamma-delta T cells (humans and mice)
- Ex vivo and in vitro evaluation of influenza-specific cells
- Analysis of influenza viral load by plaque assay
- Isolation of human PBMCs from clinical samples and buffy packs
- Mouse models of influenza virus infection