The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

Research

Virology

  • Evaluation of new antiviral drugs for hepatitis B (HBV) and hepatitis C (HCV) infection 
  • Study of HIV and HBV co-infection and HIV and HCV co-infection 
  • Studies of antiviral drug resistance 
  • Bioinformatic analysis/data mining of viral genomes 
  • Epitope mapping 
  • Antiviral drug resistance screening 
  • Vaccine efficacy (neutralisation assays) 
  • Evaluation of new molecular technologies 
  • Evaluation of diagnostic virology and microbiology laboratory platforms 
  • Epidemiological study design and analysis  
  • Estimation of disease control measure effectiveness

CONTACT

Victorian Infectious Diseases Reference Laboratory

T:+61 3 9342 9379
E:[email protected]

Microbiology

  • Genomics 
  • Short read (Illumina) and long read (PacBio) sequencing 
  • Bioinformatics 
  • Maintenance of reference collections 

CONTACT

Microbiological Diagnostic Unit Public Health Laboratory

T:+61 3 8344 5701

Advanced immune profiling

  • Advanced animal models for HIV and influenza vaccine and pathogenesis studies 
  • High level immunologic monitoring of human and primate immunology studies 
  • Analyses of a range of functional anti-viral antibody responses 
  • Interactions of nanoparticles with human immune cells 
  • Biobanks of HIV, SIV and Influenza samples from human and primate animal model studies

CONTACT

Professor Stephen Kent

T:+ 61 3 8344 9939
E:[email protected]

HIV clinical research services

  • Establishing and maintaining prospective clinical cohorts 
  • Biobanking HIV-infected and HIV-HBV co-infected individuals 
  • Early phase clinical trials 
  • Viral isolation from patient samples in patient samples including blood and tissue 
  • Quantification of HIV viral RNA and DNA 
  • In vitro HIV latency model

CONTACT

Ajantha Rhodes (Lewin/Cameron Laboratory)

T:+61 3 8344 3611
E:[email protected]

Immuno-evaluation of vaccine and immunotherapy clinical trials

  • Ex vivo and in vitro evaluation of naïve, effector and memory antigen-specific cells 
  • Tetramer detection of naïve, effector and memory antigen-specific CD8+ T cells (viral and cancer) 
  • Functional flow cytometry analysis of intracellular IFN-gamma, TNF-alpha, MIP-1beta, granzyme B and CD107a 
  • Optimised custom-designed multi-colour (>15 colours per sample) flow cytometry phenotypic analysis of innate and adaptive immune responses 
  • Induction of plasmablasts and follicular T cells following vaccination/therapy 
  • Serum levels of cytokines/chemokines by flow cytometry (>18 parameters) 
  • Generation of T cell lines in vitro 
  • Single cell RT-PCR analysis of T cell receptors for CD8+, CD4+ and gamma-delta T cells (humans and mice) 
  • Ex vivo and in vitro evaluation of influenza-specific cells 
  • Analysis of influenza viral load by plaque assay 
  • Isolation of human PBMCs from clinical samples and buffy packs 
  • Mouse models of influenza virus infection

CONTACT

Associate Professor Katherine Kedzierska

T:+61 3 8344 7962
E:[email protected]

Other Services