Continuing our endeavor to resolve the role of dendritic cells (DC) in virus infections, this project investigates the relative contributions of different DC subtypes to killer T cell priming and examines the molecular pathways involved (direct versus cross-presentation). Utilising in vivo models that remove the capacity of cells to directly present viral antigen, Sammy’s group found that robust virus-specific killer T cell responses depend on cross-presentation. They are currently delineating the underlying mechanisms.
Public Health
