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Professor Peter Revill

Professor Peter Revill

+614 1815 1722 |

Head of Regional and Global Health, VIDRL | Head of International Research Partnerships, Doherty Institute
Viral Infectious Diseases, Hepatitis
Computational Science and Genomics
The University of Melbourne, Department of Infectious Diseases, The Royal Melbourne Hospital, Victorian Infectious Diseases Reference Laboratory (VIDRL)
Lab Group(s):
Revill Group

Professor Peter Revill, AM, is Head of Regional and Global Health at the Victorian Infectious Diseases Reference Laboratory (VIDRL) at the Peter Doherty Institute for Infection and Immunity, where he is also head of International Research Partnerships and co-lead of the Global Health Cross-cutting Discipline. Professor Revill has a strong national and international reputation in hepatitis B virus (HBV) virology and in 2016 he co-founded the global HBV cure initiative, the International Coalition to Eliminate Hepatitis B (ICE-HBV). In 2021 he was appointed theme leader in Virology by the Australian Society for Microbiology and in 2022 he was recognized in the Queen’s Birthday Order of Australia honors for services to Microbiology and Immunology.

  • Key Achievements
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    • Identifying novel biomarkers of HBV treatment response

      Peter is lead investigator on multiple studies interrogating novel biomarkers of treatment response in the setting of antiviral therapy. His team utilises next generation sequencing (Illumina miseq) to sequence the complete HBV genome, to determine the impact of sequence diversity and identify specific mutations associated with adverse or successful treatment. Peter also has an interest in the role of the innate immune response in treatment response, with his team showing that some innate immune responses are predicative of response in the setting of interferon treatment. Importantly, the ability of HBV to down-regulate innate immune responses varies by HBV genotype.

    • Novel approaches to HBV cure

      HBV is currently incurable. The HBV X protein is critical for transcription of viral cccDNA, the nuclear form of HBV, which represents a major impediment to HBV cure, as it is not targeted by current antiviral therapies. Peter’s team will utilise cell culture models to investigate the role of the HBx protein in HBV infection, replication and cccDNA stability, to assess the feasibility of HBx as a novel therapeutic target that may lead to HBV cure.

    • The emergence of African HBV genotypes in Australian pediatric patients

      Although HBV is mostly transmitted by “mother to baby” worldwide, there have been few studies of HBV in the pediatric setting. HBV chronically infects over 75 million people in Africa where novel genotypes are associated with rapid progression to liver cancer in young males (subtype A1) or reduced vaccine efficacy (genotype E). In collaboration with Associate Professor Winita Hardikar and Dr Liz Bannister at the Royal Children’s Hospital, Peter’s team is investigating the distribution, natural history and molecular virology of African HBV genotypes in a pediatric setting.  

    • The role of genotype in HBV pathogenesis

      HBV exists as nine major genotypes, one minor genotype, and over 40 subtypes globally.  HBV natural history, disease progression and treatment response varies markedly for many genotypes and subtypes, for reasons that are unclear. Peter’s team has established an extensive panel of replication competent cDNA clones of all major genotypes and many important subtypes, enabling direct comparison of HBV replication, using cell culture and more recently (in collaboration with Dr Marc Pellegrini at the Walter and Eliza Hall Institute) murine models. He has also established collaborations with international investigators using these clones to interrogate the role of genotype in treatment response.  

    • The role of splicing in HBV pathogenesis

      At least 14 different splice-derived RNA or DNA variants have been identified to date in cells or serum obtained from persons with chronic HBV, or from cell cultures transfected with infectious HBV cDNAs. The most frequently detected HBV spliced RNA/DNA is a 1.9 kb molecule termed Sp1, generated by removal of a 1.3 kb intron from the pre-genomic RNA.  We have shown that the presence of spliced variants in patient serum is predictive of liver cancer. Peter is interested to determine the mechanisms by which this occurs and whether spliced variants can be specifically targeted for removal using RNAi.

    Research Groups
    • Revill Group

      The Revill Group is focusing on developing novel mechanisms to cure chronic hepatitis B disease, targeting multiple aspects of the virus replication cycle and stimulating antiviral host immune responses 

      Lab Team

      Revill Group

      • Head of Regional and Global Health, VIDRL | Head of International Research Partnerships, Doherty Institute
      • Senior Medical Scientist
      • Medical Scientist
      • Zak Janetzki
        PhD Candidate
      • Mina Takawy
        Medical Scientist
      • Olivia Maslac
        Medical Scientist
      • Yianni Droungas
        Medical Scientist
      • Romaine Perera
        Honours Student

Full University of Melbourne profile