Elizabeth Vincan Project A
Adult stem cells are the cell-of-origin of cancer. Stem cells are absolutely dependent on tightly controlled Wnt signalling, however, these cells initiate cancer if the Wnt pathway is abnormally switched on. Elizabeth’s research shows that the level of Wnt activity in the cancer cells is critical to cancer growth and that this level is modulated by additional signalling from the Wnt receptor complex. Using mini-gut, -liver and -stomach organoid technology developed by her collaborators, Professors Hans Clevers and Nick Barker, her group demonstrated potent anti-tumour effects by blocking Wnt receptors. This is being developed as targeted therapy for gastrointestinal cancers.
Elizabeth Vincan Project B
Some human viruses are exquisitely selective and only infect human cells. This has hampered studies to prevent and control infection. To fill this gap in knowledge, Elizabeth’s team has established patient-derived organoid models that faithfully recapitulate the key features of natural infection. Established from resected and biopsy tissue pieces, organoids contain stem cells that are coerced to generate tiny replicas that faithfully recapitulate the essential architecture and function of their tissue of origin. This enables anti-viral testing, toxicology and vaccine development using adult human tissue. We are establishing diverse human organoid models to combat emerging infections of public health importance.
Professor Elizabeth Vincan
(03) 9342 9348 | [email protected]
- Senior Medical Scientist / Laboratory Head
- Host Pathogens Interactions , Viral Infectious Diseases, Emerging Infections
- Discovery Research, Public Health, Translational and Clinical Research
- The University of Melbourne, Victorian Infectious Diseases Reference Laboratory (VIDRL)
- Lab Group(s):
- Vincan Group
Professor Elizabeth Vincan is a Senior Medical Scientist and Researcher at VIDRL and Doherty Department, University of Melbourne. Her role as Medical Scientist is to translate research discoveries into a clinical setting. Elizabeth is also a laboratory head at the Doherty Institute, University of Melbourne. Her team of researchers investigate how normal stem cells become cancer cells and the role viral infection plays in this change. Elizabeth is an honorary in the Department of Anatomy and Neuroscience at the University and is an Adjunct Professor within the School of Pharmacy and Biomedical Sciences at Curtin University in Western Australia.