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Elizabeth Vincan Project A
Adult stem cells are the cell-of-origin of cancer. Stem cells are absolutely dependent on tightly controlled Wnt signalling, however, these cells initiate cancer if the Wnt pathway is abnormally switched on. Elizabeth’s research shows that the level of Wnt activity in the cancer cells is critical to cancer growth and that this level is modulated by additional signalling from the Wnt receptor complex. Using mini-gut, -liver and -stomach organoid technology developed by her collaborators, Professors Hans Clevers and Nick Barker, her group demonstrated potent anti-tumour effects by blocking Wnt receptors. This is being developed as targeted therapy for gastrointestinal cancers.
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Elizabeth Vincan Project B
Some human viruses are exquisitely selective and only infect human cells. This has hampered studies to prevent and control infection. To fill this gap in knowledge, Elizabeth’s team has established patient-derived organoid models that faithfully recapitulate the key features of natural infection. Established from resected and biopsy tissue pieces, organoids contain stem cells that are coerced to generate tiny replicas that faithfully recapitulate the essential architecture and function of their tissue of origin. This enables anti-viral testing, toxicology and vaccine development using adult human tissue. We are establishing diverse human organoid models to combat emerging infections of public health importance.
Professor Elizabeth Vincan
(03) 9342 9348 | evincan@unimelb.edu.au
- Position:
- Principal Medical Scientist / Laboratory Head
- Theme(s):
- Viral Infectious Diseases, Host Pathogens Interactions , Emerging Infections
- Discipline(s):
- Discovery Research, Public Health, Translational and Clinical Research
- Unit(s):
- The University of Melbourne, Victorian Infectious Diseases Reference Laboratory (VIDRL), Department of Infectious Diseases
- Lab Group(s):
- Vincan Group
Professor Elizabeth Vincan is a Principal Medical Scientist and Researcher at VIDRL and the Department of Infectious Diseases, Melbourne Medical School, University of Melbourne. Her role as Medical Scientist is to translate research discoveries into a clinical setting. Elizabeth is also a laboratory head at the Doherty Institute. Her team of researchers investigate how normal stem cells become cancer cells and the role Wnt signalling plays in this change. Elizabeth is an Adjunct Professor within the Curtin Medical School, Curtin University, Perth, Western Australia.
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Key Achievements
Publications
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Elizabeth completed her PhD at the University of Melbourne in 1995. Her experimental work, conducted at Fairfield Infectious Diseases Hospital, identified and characterised novel macrophage tropic HIV isolates. Her postdoctorals at the Baker Institute and Peter MacCallum Cancer Centre led to a keen interest in signal transduction and her lab's research focus: the Wnt signalling pathway in cancer. She is internationally recognised as an expert in Wnt signalling and was the convenor of the first international Wnt meeting, and the first EMBO workshop, to be held in Australia. She has attracted numerous grants and awards to fund her research.
ProjectsLoading ORCID data…Research Groups-
Vincan Group
Elizabeth’s group investigates novel ways to block cancer growth with a focus on the gastrointestinal tract – stomach, bowel and liver. A cell-cell communication pathway called Wnt is hyperactive in these cancers. Their research shows inhibiting Wnt has potent anti-cancer effects.
Lab Team
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Principal Medical Scientist / Laboratory Head
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Dr Bang Manh TranResearch Fellow
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Dr Aurora MessinaSenior Research Fellow
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Dr Hoanh TranSenior Research Fellow (Honorary)
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Dr Toby PhesseSenior Research Fellow (Honorary)
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Research Fellow (Honorary)
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Research Fellow
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Jean MoselenResearch Assistant/Medical Scientist
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Dr Georgina RiddoughPhD student
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