Intracellular survival and replication of Coxiella burnetii
Hayley’s laboratory is interested in understanding the causative agent of Q fever, Coxiella burnetii. Coxiella replicates inside a unique lysosome-derived vacuole within host cells. Essential to this process is the Dot/Icm Type IV secretion system that translocates over 100 Coxiella virulence proteins, termed effectors, into the host cell. Hayley’s group’s research focuses on characterising the biochemical functions and relative importance of these effectors. In addition, the Dot/Icm system is only active when the bacteria reach an acidified vacuole. How Coxiella senses these environmental cues and what the host triggers are that contribute to Dot/Icm activation are also under investigation.
Manipulation of eukaryotic vesicular trafficking by Legionella longbeachae
Worldwide Legionnaires’ disease is predominantly caused by Legionella pneumophila, however in Australia, L. longbeachae is an equally prevalent cause of this infectious pneumonia. These pathogens also rely on a Dot/Icm Type IV secretion system for intracellular replication. Hayley’s group is interested in characterising how L. longbeachae replicates within human host cells. Despite establishing a replicative vacuole that is phenotypically similar to pneumophila, longbeachae lacks many of the Dot/Icm effectors known to manipulate eukaryotic cell trafficking. Hayley’s group is characterising the unique cohort of effectors translocated by longbeachae and how they function to establish the longbeachae replicative vacuole.
Associate Professor Hayley Newton
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Associate Professor Hayley Newton completed her PhD at Monash University in 2007. In 2009, she commenced a National Health and Medical Research Council (NHMRC) Training Fellowship within the laboratory of Professor Craig Roy at Yale University. Here she worked extensively to develop an understanding of the pathogenesis of the intracellular bacterial pathogen Coxiella burnetii. Hayley moved to the Department of Microbiology and Immunology in 2013 and has established a research program examining the virulence strategies of intracellular bacterial pathogens. In 2020, Hayley was appointed the Department of Microbiology and Immunology Graduate Research Coordinator and she is the co-director of the Doherty PhD Program.