6bb3 Thailand | Doherty Website

The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

Thailand

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Lewin group
Project leader(s): Professor Sharon Lewin
Collaborator(s): Thai Red Cross Society 

A randomized study to compare the efficacy of vorinostat/hydroxychloroquine/maraviroc (VHM) in controlling HIV after treatment interruption in subjects who initiated ART during acute HIV infection.

Studies have shown that while HIV replication is suppressed while an individual is on treatment, the virus can hide in areas called virus reservoirs. Once treatment stops, the virus escapes from these reservoirs. Therefore, when someone is infected with HIV they must remain on treatment for life in order to keep the virus suppressed. This study looks at using a combination of novel anti-HIV treatments that will drive the virus from the reservoir during treatment interruption to allow the body’s immune cells to kill the virus and hopefully reduce or eliminate this reservoir.

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Lewin group
Project leader(s): Professor Sharon Lewin
Collaborator(s): Thai Red Cross Society 

Safety and virologic outcomes after treatment interruption in Thai patients who initiated antiretroviral therapy during early acute HIV infection.

This is a prospective cohort study of volunteers in Thailand who were diagnosed with HIV during early acute HIV infection, treated with antiretroviral therapy (ART) and subsequently enrolled in a clinical study that included a treatment interruption. This study is designed to ensure the safety of those HIV-positive volunteers. Participants will be recruited into this study for continued clinical and laboratory monitoring. Clinical study visits will take place at the Thai Red Cross AIDS Research Centre, and the optional procedures may occur at the King Chulalongkorn Memorial Hospital or the Thai Red Cross AIDS Research Centre.

Towards a Functional cure for HBV: exploiting lessons from HBV-HIV co-infection.

Doherty Department
Group leader(s): Associate Professor Joe SasadeuszDr Jennifer Audsley
Collaborator(s): Y.R. Gaitonde Centre for AIDS Research and Education

Hepatitis B virus (HBV) infection can be treated, but therapy is usually lifelong and has side effects, so a cure for HBV is very important. We work closely with colleagues in Asia where both HBV and HIV are common so this provides a unique opportunity to study HBV. We will investigate how an effective immune response against the 2 main HBV proteins is developed. If we can understand how the immune response works against HBV, this could be used to develop new therapies to develop a cure for HBV.

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