6895 Malawi | Doherty Website

The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

Malawi

Strategic alliance for Typhoid in Africa and Asia (STRATAA)

Dunstan group
Project Leader(s): Dr Sarah Dunstan
Collaborator(s): International Centre for Diarrhoeal Disease Research, BangaldeshUniversity of Oxford, UKMalawi-Liverpool-Wellcome Trust Clinical Research Program, Blantyre, MalawiOxford University Clinical Research Unit, Patan Hospital, Kathmandu, Nepal

Run throughout Malawi, Bangladesh and Nepal, the overall aim of the Strategic Alliance for Typhoid in Africa and Asia (STRATAA) is to provide the science to underpin the implementation of new vaccines for the control of enteric fever, uniquely, in different epidemiological settings in Africa and Asia. This will include (among other things); providing missing data on disease burden, antibiotic resistance and transmission needed to support and implement conjugate vaccines for enteric fever, establishing the host factors that determine susceptibility to enteric fever to inform vaccine implementation strategies, strengthen research capacity in enteric fever endemic regions of the world and provide the data for vaccine implementation advocacy. STRATAA is funded by the Wellcome Trust. 

Does SP modulate inflammatory responses in pregnant women?

Rogerson group
Project leader(s): Professor Stephen Rogerson
Collaborator(s): Malawi-Liverpool-Wellcome Trust Clinical Trust ProgrammeUniversity of Malawi College of Medicine
Funding: National Health and Medical Research Council, Bill and Melinda Gates Foundation, Joint Global Health Trials

Intermittent preventive treatment in pregnancy (IPTp) protects pregnant women from malaria. Malaria parasites are becoming resistant to most commonly used drug sulphadoxine pyrimethamine, but SP still seems to promote babies’ growth in the womb. We think SP might affect immune responses, of white blood cells and. serum acute phase proteins, in a way that provides a better environment for fetal growth, regardless of its antimalarial activity. We are using samples from big malaria prevention trials in Africa to examine this question.

0