The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

  • Research Groups
    Clinical Research

    Clinical research in HIV at the Doherty Institute is focused on understanding the barriers to curing HIV infection and developing therapeutic strategies to overcome these. In addition, the Doherty Institute has an active translational research program aimed at understanding how the immune system recovers following treatment of HIV infection and the impact of co-infections that occur commonly in low income countries, including hepatitis B virus (HBV).

    Researchers are conducting a range of observational studies understanding where the virus hides on antiviral therapy (ART), and using blood and tissue samples collected from HIV-infected participants they are identifying new drugs that activate or eliminate the virus. Other observational studies are investigating the interaction of HIV and HBV, cytomegalovirus and Cryptococcus, the frequency of HBV drug resistance in HIV-HBV co-infection, and the impact of immune activation on immune function and liver disease following ART. In addition, researchers are leading a range of multi-site local, national and international interventional studies to investigate new interventions that may eliminate persistent virus.

    Some of the Doherty Institute’s key collaborators in clinical research activities include the Department of Infectious Diseases at the Alfred Hospital; University of California San Francisco, San Francisco, USA; the Thai Red Cross, Bangkok, Thailand; and the University of Malaya, Kuala Lumpur, Malaysia.

    If you are interested in volunteering in the Doherty Institute's clinical trials, please see the projects that are now recruiting volunteers

    Now recruiting volunteers

    • HIV

      Do you have HIV and about to undergo immunotherapy for cancer?

      Volunteers needed for a study where extra blood tests will be taken during immunotherapy treatment for cancer.

      Learn more

    • HIV

      Would you like to help researchers eradicate HIV?

      Volunteers needed for a study where large volume of white blood cells are collected to understand where HIV hides on treatment and how to get rid of HIV from its hiding place.

      Learn more

    Current projects

    • Hepatitis HIV

      A surveillance program for the detection of hepatitis B virus (HBV) resistance to tenofovir (TDF) in HIV-HBV co-infected patient

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    • HIV

      Circadian HIV RNA Oscillations and Outcomes of Stress (CHRONOS)

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    • HIV

      Dolutegravir intensification study (DIORR)

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    • HIV

      Would you like to take part in a study to see where HIV hides in the body?

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    • HIV

      Imaging the reservoir (iPHOTO3)

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    • HIV

      Investigating the effects of interferon on HIV persistence in HIV infected patients on ART

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    • Hepatitis HIV

      Long-term persistence of HIV in the liver and the clinical impact on HIV-HBV co-infection (CHHANEL)

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    • HIV

      The START HIV-1 Reservoir Sub-study

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    • Hepatitis HIV

      Towards a Functional cure for HBV: exploiting lessons from HBV-HIV co-infection

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    • HIV

      Interested in HIV cure research?

      Volunteers needed for a clinical trial to test whether high dose vitamin D can reduce HIV that persists despite antiretroviral therapy.

      Learn more