8a58 Malaria - Research | Doherty Website

The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

  • Research Groups

    Current Projects

    • Human genomics of malaria

      As part of the global MalariaGEN genomics epidemiology network (malariagen.net) and in collaboration with OUCRU Vietnam, Sarah’s group is investigating human genetic factors that protect people against severe malaria by performing genome-wide association studies of malaria.


    • Day Group

      Professor Karen Day runs a malaria research group studying the role that human variation and parasite diversity play in modulating the dynamics of chronic infection. She is also interested in the ability of malaria parasites to sense their environment by quorum sensing mechanisms to regulate parasite population in the bloodstream.


    • Haque Group

      The Haque Group use a combination of experimental models, single-cell genomics, and computational biology, to study host/pathogen interactions and immune responses during infectious disease and cancer treatment. Our goal is to develop new strategies for preventing these diseases in humans. 


    • Heath Group

      Professor Bill Heath’s group’s cellular immunology research currently focuses on understanding killer T cell function with particular reference to improved vaccination strategies and understanding malarial disease.

      Other work areas include:Immunology


    • Mueller Group

      Research in the Mueller laboratory is focused on dissecting the fundamental cellular processes involved in immune and neuro-immune responses to viruses and cancer in order to identify new targets for vaccines and novel therapeutics. We use advanced imaging and image analysis, single cell and spatial transcriptomics, transgenic mice, CRISPR editing and neuroscience tools to address these crucial knowledge gaps.

      Other work areas include:Immunology


    • Rogerson Group

      Stephen’s laboratory studies the pathogenesis and immunology of infection with the malaria parasite Plasmodium falciparum in humans. Their laboratory studies are linked to field studies, and they collaborate with leading malaria groups in Africa, Asia and Papua New Guinea. 


    Clinical Research

    Doherty Institute researchers have long standing collaborations with malaria researchers in Papua New Guinea, Malawi and Indonesia. They study the effects of malaria infection on pregnant women, their babies, and young children, including studies of new drugs to prevent malaria in Papua New Guinea and Malawi. Working with Malawian clinicians and scientists, they study immune responses in children with severe and uncomplicated malaria. The Doherty is leading a new Centre for Research Excellence in Malaria Elimination, focused on the Asia-Pacific Region. The CRE’s broad aim is to find better tools to detect, prevent and treat malaria in vulnerable groups. 

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