Publications

The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome

2025 · journal-article

Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial

2025 · journal-article

Abstract: Immunotherapy targeting the autoimmune process in type 1 diabetes (T1D) can delay the loss of β-cells but needs to…

Adaptive immune responses to two-dose COVID-19 vaccine series in healthy Canadian adults ≥ 50 years: a prospective, observational cohort study

2025 · journal-article

AbstractTo evaluate immune responses to COVID-19 vaccines in adults aged 50 years and older, spike protein (S)-specific antibody concentration, avidity, and…

Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein

2025 · journal-article

AbstractThe XBB.1.5 variant of SARS-CoV-2 has rapidly achieved global dominance and exhibits a high growth advantage over previous variants. Preliminary…

Dysregulated Immunity to Clostridioides difficile in IBD Patients Without a History of Recognized Infection

2025 · journal-article

Abstract Background & Aims Clostridioides difficile is a toxin-secreting bacteria that is an urgent antimicrobial resistance threat, with approximately 25%…

CD73+ CD127high long-term memory CD4 T cells are highly proliferative in response to recall antigens and are early targets in HIV-1 infection

2025 · journal-article

HIV-1 infection rapidly leads to a loss of the proliferative response of memory CD4+ T lymphocytes, when cultured with recall…

Functional immune changes are conserved in COVID-19 and trauma patients receiving intensive care

2025 · preprint

Critical illness states including COVID-19 and trauma induce profound immune dysregulation associated with morbidity and mortality. Direct comparison of these…

T‐cell activation–induced marker assays in health and disease

2025 · journal-article

A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes

2025 · journal-article

Abstract Aim We assessed the safety of ustekinumab (a monoclonal antibody used in psoriasis to target the IL-12 and IL-23…

3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility

2025 · journal-article

Macrophage MR1 antigen presentation promotes MAIT cell immunity and lung microbiota modulation

2025 · journal-article

Mucosal associated invariant T (MAIT) cells mediate tissue homeostasis and antimicrobial immunity. However, the cells that express MHC class I-related…

3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility

2024 · preprint

A portion of the genetic basis for many common autoimmune disorders has been uncovered by genome-wide association studies (GWAS), but…

Parallel analysis of multiple human memory CD4+ T‐cell subsets within antigen‐specific responses using cell proliferation dyes

2023 · journal-article

Lasting changes to circulating leukocytes in people with mild SARS-CoV-2 infections

2021 · journal-article

Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections…

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Showing publications from Dr Laura Cook (41)

Showing publications from Dr Laura Cook ⁽⁴¹⁾