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Publications

Browse publications attributed to Doherty Institute researchers

Overview

Research publications at the Doherty Institute

Our commitment to advancing knowledge in infectious diseases and immunology is reflected in a growing body of peer-reviewed research. This page provides access to published studies from our world-class scientists and collaborators, showcasing breakthroughs that inform policy, improve clinical practice, and drive innovation to improve health outcomes. Browse our collection to stay informed on the latest scientific insights shaping the future.

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Showing publications from Professor James McCarthy (309)

Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum

2025 · journal-article

A human model of Buruli ulcer: Provisional protocol for a Mycobacterium ulcerans controlled human infection study [version 2; peer review: 4 approved]

2025 · journal-article

Positron emission tomography and magnetic resonance imaging in experimental human malaria to identify organ-specific changes in morphology and glucose metabolism: A prospective cohort study.

2025 · journal-article
BackgroundPlasmodium vivax has been proposed to infect and replicate in the human spleen and bone marrow. Compared to Plasmodium falciparum,…

Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance.

2025 · journal-article
Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial drug development utilizes preclinical murine and experimental…

Semimechanistic Pharmacokinetic and Pharmacodynamic Modeling of Piperaquine in a Volunteer Infection Study with Plasmodium falciparum Blood-Stage Malaria.

2025 · journal-article
Dihydroartemisinin-piperaquine is a recommended first-line artemisinin combination therapy for Plasmodium falciparum malaria. Piperaquine is also under consideration for other antimalarial…

Molecular diagnosis of scabies using a novel probe-based polymerase chain reaction assay targeting high-copy number repetitive sequences in the Sarcoptes scabiei genome.

2025 · journal-article
BackgroundThe suboptimal sensitivity and specificity of available diagnostic methods for scabies hampers clinical management, trials of new therapies and epidemiologic…

Development and evaluation of a new Plasmodium falciparum 3D7 blood stage malaria cell bank for use in malaria volunteer infection studies.

2025 · journal-article
BackgroundNew anti-malarial therapeutics are required to counter the threat of increasing drug resistance. Malaria volunteer infection studies (VIS), particularly the…

Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels.

2025 · journal-article
BackgroundPlasmodium falciparum malaria increases plasma levels of the cytokine Fms-like tyrosine kinase 3 ligand (Flt3L), a haematopoietic factor associated with…

Safety and feasibility of apheresis to harvest and concentrate parasites from subjects with induced blood stage Plasmodium vivax infection.

2025 · journal-article
BackgroundIn the absence of a method to culture Plasmodium vivax, the only way to source parasites is ex vivo. This…

Epidemiology of soil-transmitted helminth infections in Semarang, Central Java, Indonesia.

2025 · journal-article
Soil-transmitted helminth (STH) infections are endemic in Indonesia. However, prevalence data for many parts of the country are incomplete. The…

Response to White and Watson.

2025 · journal-article

Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection.

2025 · journal-article
CD4+ T follicular helper cells (Tfh) are key drivers of antibody development. During Plasmodium falciparum malaria in children, the activation…

Retrospective Analysis Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation Offers Improvements in Efficiency of the Design of Volunteer Infection Studies for Antimalarial Drug Development.

2025 · journal-article
Volunteer infection studies using the induced blood stage malaria (IBSM) model have been shown to facilitate antimalarial drug development. Such…

Defining the antimalarial activity of cipargamin in healthy volunteers experimentally infected with blood stage Plasmodium falciparum.

2025 · journal-article
The spiroindolone cipargamin, a new antimalarial compound that inhibits Plasmodium ATP4, is currently in clinical development. This study aimed to…

A hospital-wide response to multiple outbreaks of COVID-19 in health care workers: lessons learned from the field.

2025 · journal-article

Parasite viability is a superior measure of anti-malarial drug activity in humans.

2025 · journal-article
BackgroundArtemisinin derivatives are the leading class of antimalarial drugs due to their rapid onset of action and rapid clearance of…

Safety and parasite clearance of artemisinin-resistant Plasmodium falciparum infection: A pilot and a randomised volunteer infection study in Australia.

2025 · journal-article
BackgroundArtemisinin resistance is threatening malaria control. We aimed to develop and test a human model of artemisinin-resistant (ART-R) Plasmodium falciparum…

Identifying and combating the impacts of COVID-19 on malaria.

2025 · journal-article
BackgroundThe COVID-19 pandemic has resulted in millions of infections, hundreds of thousands of deaths and major societal disruption due to…
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