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Publications

Browse publications attributed to Doherty Institute researchers

Overview

Research publications at the Doherty Institute

Our commitment to advancing knowledge in infectious diseases and immunology is reflected in a growing body of peer-reviewed research. This page provides access to published studies from our world-class scientists and collaborators, showcasing breakthroughs that inform policy, improve clinical practice, and drive innovation to improve health outcomes. Browse our collection to stay informed on the latest scientific insights shaping the future.

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Showing publications from Associate Professor Sarah Dunstan (109)

Genome graphs reveal the importance of structural variation in Mycobacterium tuberculosis evolution and drug resistance

2025 · journal-article

Antenatal screening for TB disease: a systematic review and meta-analysis.

2025 · journal-article
ObjectivesTB disease during pregnancy is associated with poor maternal and neonatal outcomes, and is a leading non-obstetric cause of maternal…

Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis-induced cytokine transcriptional responses.

2025 · journal-article
Immune and clinical outcomes to Mycobacterium tuberculosis (Mtb) infection vary greatly between individuals, yet the underlying genetic and cellular mechanisms…

Mycobacterium tuberculosis infection in pregnancy: A systematic review

2025 · journal-article

Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations

2025 · preprint
AbstractBackgroundTuberculosis (TB) continues to be a leading cause of morbidity and mortality worldwide. Past genome-wide association studies (GWAS) have explored…

Evolution and transmission of antibiotic resistance is driven by Beijing lineage Mycobacterium tuberculosis in Vietnam.

2025 · journal-article
ImportanceDrug-resistant tuberculosis (TB) infection is a growing and potent concern, and combating it will be necessary to achieve the WHO’s…

Parallel signatures of Mycobacterium tuberculosis and human Y-chromosome phylogeography support the Two Layer model of East Asian population history

2025 · journal-article

Disruption of Aldehyde Dehydrogenase 2 protects against bacterial infection

2025 · preprint
AbstractTheALDH2*2(rs671) allele is one of the most common genetic mutations in humans, yet the positive evolutionary selective pressure to maintain…

REL and BHLHE40 Variants Are Associated with IL-12 and IL-10 Responses and Tuberculosis Risk

2025 · journal-article

Sources of Multidrug Resistance in Patients With Previous Isoniazid-Resistant Tuberculosis Identified Using Whole Genome Sequencing: A Longitudinal Cohort Study

2025 · journal-article
Abstract Background Meta-analysis of patients with isoniazid-resistant tuberculosis (TB) given standard first-line anti-TB treatment indicated an increased risk of multidrug-resistant…

Empirical ways to identify novel Bedaquiline resistance mutations in AtpE

2025 · journal-article

Genome graphs reveal the importance of structural variation in Mycobacterium tuberculosis evolution and drug resistance

2025 · preprint
Abstract Structural variants (SVs) are increasingly recognized as key drivers of bacterial evolution, yet their role has not been explored…

Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance

2025 · preprint
Summary Mycobacterium tuberculosis(Mtb) has co-evolved with humans for thousands of years causing variation in virulence, transmissibility, and disease phenotypes. To…

Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study.

2024 · journal-article
BackgroundEnteric fever is a serious public health concern. The causative agents, Salmonella enterica serovars Typhi and Paratyphi A, frequently have…

Identification of bacterial determinants of tuberculosis infection and treatment outcomes: a phenogenomic analysis of clinical strains.

2024 · journal-article
BackgroundBacterial diversity could contribute to the diversity of tuberculosis infection and treatment outcomes observed clinically, but the biological basis of…

Interplay Between the Gut Microbiome and Typhoid Fever: Insights from Endemic Countries and a Controlled Human Infection Model

2024 · preprint
AbstractTyphoid fever is a systemic infection caused bySalmonella entericaserovar Typhi (S.Typhi) invasion from the gut lumen. Transmission between people occurs…

MUC5AC Genetic Variation Is Associated With Tuberculous Meningitis Cerebral Spinal Fluid Cytokine Responses and Mortality

2023 · journal-article
Abstract Background The purpose of this study was to assess if single nucleotide polymorphisms (SNPs) in lung mucins MUC5B and…

Direct inference and control of genetic population structure from RNA sequencing data

2023 · journal-article
AbstractRNAseq data can be used to infer genetic variants, yet its use for estimating genetic population structure remains underexplored. Here,…
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