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Navigating the terrain of neutrophil extracellular traps in severe malaria pathogenesis


  • Saeed, Maria
  • Aitken, Elizabeth H.
  • Rogerson, Stephen J.


Trends in Parasitology, Volume 40, Issue 4, 2024-04-30

Article Link: Click here

Du, Ren, et al. recently showed in a Plasmodium berghei ANKA (PbA) experimental malaria model that phosphatase of regenerating liver 2 (PRL2) regulates neutrophil extracellular traps (NETs) in severe malaria (SM)-related acute lung injury (ALI). PRL2 deficiency caused SM with ALI in a mouse model by increasing NETs in pulmonary tissue; hydroxychloroquine (HCQ) may ameliorate this.