γδ T cells unveil invisible tumors

Authors:

• Koay, Hui-Fern
• Lynch, Lydia

Details:

Trends in Immunology, Volume 44, Issue 3, 2023-03-31

Article Link: Click here

Tumors can evade conventional T cell recognition by rendering the HLA class I antigen presentation system defective. In a recent study, de Vries et al . reveal γδ T cells as key contributors to the efficacy of immune checkpoint blockade (ICB) against HLA-I-silenced cancers, highlighting a novel layer of surveillance against immune escape by tumors.