γδ T cells unveil invisible tumors
- Koay, Hui-Fern
- Lynch, Lydia
Trends in Immunology, Volume 44, Issue 3, 2023-03-31
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Tumors can evade conventional T cell recognition by rendering the HLA class I antigen presentation system defective. In a recent study, de Vries et al . reveal γδ T cells as key contributors to the efficacy of immune checkpoint blockade (ICB) against HLA-I-silenced cancers, highlighting a novel layer of surveillance against immune escape by tumors.