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The Batman and Robin of liver-stage immunity to malaria


  • Heath, William R.
  • Holz, Lauren E.
  • Fernandez-Ruiz, Daniel


Trends in Parasitology, Volume 38, Issue 1, 2022-01-31

Article Link: Click here

Malaria parasites replicate within the liver shortly after infection. This stage can be controlled by CD8 T cells, but which subsets undertake this function is unclear. Lefebvre et al. now elegantly show that effector memory T (TEM) cells are avid participants, working as a dynamic duo with liver tissue-resident memory T (TRM) cells to combat infection.