The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


21 Feb 2022

Setting it Straight: Viruses, Vaccines and COVID-19: the recall and naïve responses to Omicron

The site of any immune response is dictated initially by where a foreign (non-self) product (mRNA, protein or peptide) is introduced into our body, then by the lymphatic drainage from that site. For a vaccine injected into the arm that’s the axillary lymph nodes (ALNs) in the armpit (#85-90), for an infection in the nose it’s (initially at least) the mucosal associated lymphoid tissue (MALT, #38) of the adenoids and tonsils and the regional cervical lymph nodes (CLNs) of the neck. Also involved from virus-invasion day one may be the small amount of nasal associated lymphoid tissue (NALT) then, as the infection spreads, the bronchus associated lymphoid tissue (BALT) and the mediastinal lymph nodes (MLNs) that drain the lung.