21 Feb 2022
Setting it Straight: Viruses, Vaccines and COVID-19: the recall and naïve responses to Omicron
The site of any immune response is dictated initially by where a foreign (non-self) product (mRNA, protein or peptide) is introduced into our body, then by the lymphatic drainage from that site. For a vaccine injected into the arm that’s the axillary lymph nodes (ALNs) in the armpit (#85-90), for an infection in the nose it’s (initially at least) the mucosal associated lymphoid tissue (MALT, #38) of the adenoids and tonsils and the regional cervical lymph nodes (CLNs) of the neck. Also involved from virus-invasion day one may be the small amount of nasal associated lymphoid tissue (NALT) then, as the infection spreads, the bronchus associated lymphoid tissue (BALT) and the mediastinal lymph nodes (MLNs) that drain the lung.