The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


31 May 2021

Setting it Straight: The scientific defence that brings us to Phase III, the penultimate trial

The power of modern molecular science is such that, adapting technology developed for other pathogens, making the candidate mRNA (Pfizer BioNTech and Moderna) and adenovirus-vectored (AstraZeneca, Johnson and Johnson and Sputnik) vaccines (#49, #50) to counter SARS-CoV-2 infection was reasonably straightforward. And, once naturally occurring (in people) SARS-CoV-2 variants that also infect laboratory mice emerged – the initial strains only infected hamsters, mustelids (ferrets and mink) and monkeys – vaccine protection studies in animals became much more feasible.