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As discussed over the past couple of weeks (#108, #109), it’s reasonable to think that some of the variability in Long COVID (LC) will reflect what happened during the acute phase of the disease. Those who required hospitalization may, after discharge, be suffering persistent health impairment as a consequence of severe damage to body organs, especially the lungs, heart and kidney. Such effects, which may at least partly resolve with compensatory tissue repair over time, are likely to be most apparent for those who required ICU support. Post Intensive Care Syndrome (PICS) is well known for other conditions, including severe influenza.