Events

At this research seminar, Dr Christophe Paget, Research Director at Inserm and French National Research Agency (ANR) Fellow from the University of Tours presents Innate-like T cells: From development to therapeutic applications.

Abstract

Christophe Paget is a Research Director at Inserm and Head of the newly-created Team "Biology of Innate T cells & Lung Immunity" at the Study Center for Respiratory Diseases in Tours (University of Tours), France. Over the last 15 years, Dr Paget has developed a strong expertise in the field of Innate T cells' biology including the molecular mechanisms associated to their development and effector fate decisions as well as their functions and associated mechanisms during lung infections.

During this seminar, Dr Paget will present his recent team's works leading to a new developmental model for mouse iNKT thymocytes and the identification of a new subset endowed with potent cytotoxic functions. His ongoing work also indicates that innate T cells populate particular non-lymphoid tissues to exert unexpected physiological functions. His team also contributed to highlight the important role for innate T cells in lung infections by combining relevant experimental models and clinical studies. A peculiar focus on MAIT cells will be given. Finally, his research has revealed that innate T cells are instrumental to fight lung infections in prophylactic settings. Here, he will present his current work that aims at targeting MAIT cells' antimicrobial functions to combat lung infections.