The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

One Health (Past Projects)

Cefotaxime Resistant Salmonella enteritidis Serovar

Project Summary

Salmonellosis is an important cause of bacterial gastroenteritis in Australia. Reported rates of antimicrobial resistance in locally-acquired strains of Salmonella enterica serovar Typhimurium are low compared with other countries, with no third-generation cephalosporin resistance reported.  Since 2012, resistance to cefotaxime has been noted in multi-drug resistant (MDR) isolates of S. enterica serovar Typhimurium phage-type 44 (STm44) obtained from humans and food animals in Victoria.

This study aims to characterise the resistance mechanism and investigate the emergence of this non-susceptible strain, using a combination of phenotypic methods and whole-genome sequencing (WGS).

Project Partners

OzFoodNet, ACT, Australia

Department of Health and Human Services, Victoria, Australia


Emergence of multidrug resistance in locally-acquired human infections with Salmonella Typhimurium in Australia owing to a new clade harbouring blaCTX-M-9.

Sparham SJ, Kwong JC, Valcanis M, Easton M, Trott DJ, Seemann T, Stinear TP, Howden BP. International Journal of Antimicrobial Agents. 2017;50(1):101-5. doi: 10.1016/j.ijantimicag.2017.02.014

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