The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

Community and Vaccine-Preventable Invasive Bacterial Pathogens (Past Projects)

Genomic investigation of an invasive Group A Streptococcus outbreak

Project Summary

Group A Streptococcus are an important cause of human disease and are associated with significant rates of morbidity and mortality around the world.

An outbreak of emm81 GAS occurred in a care facility in late 2014.  There were five fatalities within one week, and a number of staff were also colonised. Preliminary WGS showed that the outbreak strain contains a phage that was absent in non-outbreak isolates. Whether this phage is carried by other emm81 isolates is unknown.

The aims of this project are:

  1. To sequence a collection of historic emm81 isolates to determine the rate of carriage of this outbreak associated bacteriophage.
  2. To generate a closed emm81 genome sequence using PacBio sequencing.

Project Partners

Institute of Environmental Science and Research (ESR), New Zealand


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