Community and Vaccine-Preventable Invasive Bacterial Pathogens (Past Projects)
Genomic investigation of an invasive Group A Streptococcus outbreak
Group A Streptococcus are an important cause of human disease and are associated with significant rates of morbidity and mortality around the world.
An outbreak of emm81 GAS occurred in a care facility in late 2014. There were five fatalities within one week, and a number of staff were also colonised. Preliminary WGS showed that the outbreak strain contains a phage that was absent in non-outbreak isolates. Whether this phage is carried by other emm81 isolates is unknown.
The aims of this project are:
- To sequence a collection of historic emm81 isolates to determine the rate of carriage of this outbreak associated bacteriophage.
- To generate a closed emm81 genome sequence using PacBio sequencing.
Institute of Environmental Science and Research (ESR), New Zealand