Hospital and Healthcare Pathogens
Genomic Epidemiology of Invasive E. coli and K. pneumoniae in Australia
The Australian Group on Antimicrobial Resistance (AGAR) commenced surveillance of the key Gram-negative pathogens, Escherichia coli and Klebsiella species in 1992. Since then AGAR prospectively collects resistant isolates from numerous healthcare institutions around Australia. These species are known to provide valuable insight into the development of multidrug resistance and the emergence of resistances in other Gram negative bacteria.
As part of this project approximately 1000 isolates will be subjected to whole genome sequencing. The aims of the project are (1) to use genomics to monitor the resistance profile of blood isolates collected from hospital patients (2) to determine the extent to which multidrug resistance exists in these species and (3) to detect emerging resistance to newer last line agents such as carbapenem.
Australian Group on Antimicrobial Resistance (AGAR), Australia