Study at the Doherty Institute

Barrow group

The Barrow group is interested in innate immune recognition programs, in particular a new immunological recognition strategy termed ‘growth factor surveillance’.

Bioassay Group

The Bioassay group sits in the Bioanalytical Sciences Department within the Recombinant Product Development division (Parkville). The overall aim of this group is to develop fit-for-purpose cell-based assays to support clinical trials and for the functional characterization of new products.

Coin group

The Coin group develops genomic and transcriptomic tools to develop biomarkers for rapid characterization of disease state and prediction of drug susceptibility, with the aim of decreasing the time taken from hospital admission to administering the right treatment.

Davies group

The Davies group aims to apply genome sequencing methodologies and bioinformatics approaches to understand the evolution and transmission of bacterial pathogens.

Dunstan group

The Dunstan group uses host and pathogen genomics to understand infectious diseases. We perform genome-wide association studies of the human host, genomic studies of the infecting pathogen, and investigate the interaction of both genomes in disease.

Fazakerley group

The Fazakerley group’s main interest is the transmission and pathogenesis of arthropod vector-borne (arbovirus) infections of the central nervous system (CNS).

Godfrey group

The Godfrey group has a strong track record in the field of unconventional T cells with a focus on CD1 restricted cells (NKT cells); MR1-restricted T cells (MAIT cells) and gamma delta T cells (1). These cells play a key role in many different diseases.

Haque group

The Haque group is interested in studying T cell responses during infectious disease and in cancer. We specialize in studying these cells using a relatively recent technique called “single-cell genomics”.

Howden group

The Howden laboratory is focused on understanding how various antimicrobial resistant pathogens cause disease and develop antimicrobial resistance.

Kallies group

The Kallies group has done pioneering work in understanding the role of immune cells in infection, metabolic diseases and cancer.

Kent group

The Kent group has an interest in understanding how the immune response can be harnessed in the control of infectious pathogens including SARS-CoV2, HIV, Mycobacterium tuberculosis and influenza.

Lawson group

The Lawson group is focused on understanding how protein misfolding in the central and enteric nervous system gives rise to diseases such as prion and Parkinson’s diseases, with a focus on diagnosis, treatment and prevention, as well as understanding how the normal function of these proteins may contribute to diseases such as cancer.

Lewin group

The main focus of the Lewin group is to understand why HIV infection persists on antiretroviral therapy and to develop new strategies to eliminate latent HIV.

Mantamadiotis group

The Mantamadiotis group’s research aims to understand how the tumor microenvironment, including immune cells, contribute to oncogenesis and how to modulate the immune system to improve current brain cancer therapy.

McCluskey group

The McCluskey group are an internationally leading laboratory in MAIT cell research, having made significant breakthrough discoveries in MAIT cell immunity.

McDevitt group

The chemistry in every cell in all forms of life is dependent on metal ions. Research in the McDevitt group seeks to understand how bacterial pathogens acquire and use metal ions and how this shapes the host-pathogen interaction during infection.

Mackenzie group

The Mackenzie group investigates the intracellular replication of flaviviruses and noroviruses to understand how replication influences cellular functions and immune dysfunction.

McVernon group

The McVernon group uses established and emerging biostatistical, epidemiologic and modelling methods to address infectious diseases questions of public health relevance.

Mueller group

Research in the Mueller group is focused on examining immune responses to acute and chronic viral infections and to tumours.

National Centre for Antimicrobial Stewardship

Research undertaken by NCAS aims to understand current antimicrobial prescribing behaviour in human and animal healthcare settings, and develop, implement and evaluate practical strategies to improve the way that antimicrobial drugs are used within Australia.

Newton group

The Newton group uses a range of molecular and cell biology approaches to investigate the host-pathogen interactions that occur during infection with intracellular bacterial pathogens.

Pidot group

The Pidot group is a multi-disciplinary team that works across microbiology, genomics and biological chemistry to identify new antimicrobials and investigate their biosynthesis.

Purcell group

The Purcell group investigates the HIV-1 and HTLV-1 human retroviruses that cause AIDS, leukaemia and inflammatory pathogenesis respectively.

Reading group

The Reading group have expertise in understanding viral attachment factors, cellular receptors and entry pathways, virus-induced activation of host genes and the mechanisms by which intracellular host proteins can block virus replication.

Revill group

The Revill group’s work is focused on the molecular virology of the hepatitis B virus (HBV), which is one of the most important human pathogens, infecting 257 million people worldwide, including 239,000 Australians.

Rogerson group

The Rogerson group studies the pathogenesis and immunity of malaria in the human host, using in vitro models and clinical samples from individuals in malariaaffected countries.

Satzke group

The Satzke group conducts research in a clinicallyrelevant context. We focus on the microbiology of two pathogens of major global health importance (pneumococcus and Group A Streptococcus) to understand their pathogenesis, interaction with viruses, and how infections can be best prevented with vaccines.

Scott group

The Scott lab focuses on the application of mass spectrometry (MS)-based methodologies to characterise microbial systems. The key focus of the lab is understanding how pathogens of the Burkholderia genus cause disease and why proteins decorated with carbohydrates influence Burkholderia pathogenesis.

Stinear group

The Stinear group study bacteria that can infect humans and cause disease and we study human immune responses to those bacteria. We make mutants. We uncover molecular mechanisms of pathogenesis. We discover new antibiotics. We make vaccines. We create new diagnostic tests. We track disease outbreaks, . We sequence genomes and we expose dodgy science.

Strugnell group

The Strugnell Lab has two major research interests. Firstly, in driving immunity to Salmonella spp. The other major interest is in Klebsiella pneumoniae, an encapsulated opportunistic pathogen that readily forms biofilms.

VICNISS group

The Victorian Healthcare Associated Infection Surveillance System (VICNISS) Coordinating Centre is responsible for surveillance of healthcare-associated infections in Victorian public and private hospitals, and the aged care sector.

Villadangos group

The Villadangos group studies the first event that triggers adaptive immune responses: the presentation of pathogen or tumour antigens to T cells by Dendritic Cells, B cells and Macrophages.

Wakim group

The Wakim group research focus is understanding how T cells resident along the respiratory tract can be utilised to protect against influenza virus infection.

WHO Collaborating Centre for Reference and Research on Influenza

A key goal of our work is to identify strategies to improve the immunogenicity and, therefore, effectiveness of influenza vaccines.