Project: Understanding the heterogeneity of intestinal resident memory T cells (TRMs) and their role in homeostasis
In this project, we aim to identify mechanisms that regulate the development and heterogeneity of TRM cells in the intestine. Using novel genetic tools and various infection models, we aim to identify the function of TRM in regulating microbiota composition and intestinal homeostasis during homeostasis and disease.
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The work of the Kallies group focusses on understanding the molecular regulation of immunity. Our research has established the important functions of several transcription factors and discovered key molecular circuits in lymphocyte differentiation. Current studies focus on molecular regulation of immune cell differentiation and function in non-lymphoid tissues, including tumors, and on metabolic control of lymphocyte differentiation. For our research, we are using preclinical models of infection and malignant disease combined with next generation sequencing technology and bioinformatics. Our discoveries have opened new avenues to targeting plasma cells as well as T cells in autoimmunity, metabolic disease and cancer.
Kallies Group Current Projects
Understanding the heterogeneity of intestinal resident memory T cells (TRMs) and their role in homeostasis
PhD/MPhil, Master of Biomedical Science, Honours