Project: Understanding the entry pathways and viral life cycle of influenza A virus (IAV) in host epithelial cells and immune cells
We have developed experimental approaches to examine and understand the life cycle of IAV in epithelial cells (where replication is productive, resulting in virus growth) and macrophages (where replication is abortive and infectious virus is not released). Moreover, will investigate the viral determinants of highly pathogenic avian influenza (HPAI) H5N1 that allow them to evade host restriction to replicate productively in airway macrophages.
The Reading Group have expertise in understanding viral attachment factors, cellular receptors and entry pathways, virus-induced activation of host genes and the mechanisms by which intracellular host proteins can block virus replication.
Our current research is focussed on
(i) understanding the entry pathways and viral life cycle of respiratory viruses in host epithelial cells and immune cells
(ii) investigating host factors (viral restriction factors such as interferon stimulated genes) that control the replication of respiratory viruses in epithelial cells vs immune cells.
Reading Group Current Projects
PhD/MPhil, Master of Biomedical Science
Understanding the entry pathways and viral life cycle of influenza A virus (IAV) in host epithelial cells and immune cells
PhD/MPhil, Master of Biomedical Science, Honours