The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: Understanding the entry pathways and viral life cycle of influenza A virus (IAV) in host epithelial cells and immune cells

Reading Group

We have developed experimental approaches to examine and understand the life cycle of IAV in epithelial cells (where replication is productive, resulting in virus growth) and macrophages (where replication is abortive and infectious virus is not released). Moreover, will investigate the viral determinants of highly pathogenic avian influenza (HPAI) H5N1 that allow them to evade host restriction to replicate productively in airway macrophages.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Sarah Londrigan

Project Co-supervisor

Professor Patrick Reading

Project availability
Master of Biomedical Science

Reading Group

2 vacancies

Viral Infectious Diseases
Bacterial and Parasitic Infections
Cross Cutting Disciplines

The Reading Group have expertise in understanding viral attachment factors, cellular receptors and entry pathways, virus-induced activation of host genes and the mechanisms by which intracellular host proteins can block virus replication.

Our current research is focussed on

(i) understanding the entry pathways and viral life cycle of respiratory viruses in host epithelial cells and immune cells

(ii) investigating host factors (viral restriction factors such as interferon stimulated genes) that control the replication of respiratory viruses in epithelial cells vs immune cells.