Project: Understanding Staphylococcus aureus adaptation to intracellular lifestyle
Howden Group
Staphylococcus aureus can adopt an intracellular lifestyle to persist and evade both bactericidal immune responses and antibiotics. Transitions from cytotoxic to intracellular persistence phenotypes can occur in clinical isolates of S. aureus, and these are mediated by mutations. This project will employ a functional genomics approach, combining ex vivo evolution of S. aureus within human cells, whole genome sequencing, and Transposon sequencing analysis, to understand this key aspect of S. aureus pathogenesis.
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Howden Group
2 vacancies
The Howden lab has a strong interest in understanding the various facets of antimcirobial resistance (AMR), spanning discovery research in AMR mechanisms and evolution through to translational projects to imporve AMR detection and surveillance, and treatment of resistant infections.
Howden Group Current Projects
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Assessing the suitability of lateral flow devices for highly pathogenic avian influenza surveillance
Honours
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Exploring the genomic landscape of Staphylococcus aureus antibiotic adaptation
Master of Biomedical Science, Honours
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Understanding Staphylococcus aureus adaptation to intracellular lifestyle
PhD/MPhil, Master of Biomedical Science, Honours
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Defining the impact of recurrent natural Staphylococcus aureus mutations on virulence and anti-microbial resistance
PhD/MPhil, Master of Biomedical Science, Honours
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Investigating novel strategies to study drug synergy/antagonism in combination therapy for key bacterial pathogens
PhD/MPhil, Master of Biomedical Science, Honours
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Exploring resistance to old antibiotics in multi-drug resistance gram-negative bacteria using functional genomics
PhD/MPhil, Master of Biomedical Science, Honours
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Expanding the diversity of animal astroviruses through transcriptome mining
Honours
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Ecology and diversity of Avian orthoavulavirus 1, the causative agent of Newcastle Disease virus, in Australian wild birds
Honours
Research degrees at the Doherty Institute are administered by the University of Melbourne.