The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Understanding pneumococcal pathogenesis

Satzke Group

Streptococcus pneumoniae (the pneumococcus) is the most common cause of community-acquired pneumonia and a leading killer of children world-wide. However, it is also commonly found as an asymptomatic coloniser of the upper respiratory tract (carriage). Pneumococcal carriage is an important reservoir for transmission and a precursor to disease. In this project, you will identify novel genes and characterise their role in pneumococcal carriage and/or disease. Key approaches to this project include: genetic manipulation of pneumococcal isolates, working with in vitro and/or in vivo models such respiratory cells from patients grown as air-liquid interface and mouse models, as well as microbiological and immunological analysis of local and systemic samples. Your research will provide new insights into how pneumococci colonise and cause disease.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Associate Professor Catherine Satzke

Project Co-supervisor

Dr Sam Manna

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Satzke Group

catherine.satzke@mcri.edu.au

2 vacancies

Themes
Host Pathogens Interactions
Cross Cutting Disciplines
Epidemiology
Global Health
Translational and Clinical Research

The Satzke group conducts research in a clinically-relevant context. We focus on the microbiology of two pathogens of major global health importance (pneumococcus and group A streptococcus) to understand their pathogenesis, interaction with viruses, and how infections can be best prevented with vaccines. We collaborate closely with immunologists, clinicians and epidemiologists, including in countries in the Asia-Pacific region, to facilitate translation and global impact.

Our laboratory also has the resources and expertise to adapt flexibly depending on the findings you generate throughout the year, or to additional COVID-19 restrictions. These include access to clinical and laboratory isolates, clinical samples, and bioinformatics expertise.


Satzke Group Current Projects