The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Understanding persistence of antibody immunity to malaria

Rogerson Group

Understanding how antibody helps protect against malaria is important for the design of vaccines and therapeutics. We have developed a new whole blood assay that allows us to measure how antibody-coated malaria infected red blood cells are taken up by both monocytes and neutrophils. You will adapt this assay to study how antigen coated beads opsonised by antibody are taken up these cells, and how antibody and complement work together to clear malaria infected cells and beads. You will learn how to culture malaria infected red blood cells and advanced flow cytometry techniques to analyse these interactions.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Stephen Rogerson

Project Co-supervisor

Dr Elizabeth Aitken

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Rogerson Group

elizabeth.aitken@unimelb.edu.au

4 vacancies

Themes
Immunology
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research
Global Health
Translational and Clinical Research

The Rogerson group studies the pathogenesis and immunity of malaria in the human host, using in vitro models and clinical samples from individuals in malaria-affected countries. We study how malaria in the mother affects her placenta, and the growth and development of her baby, and why some children develop life-threatening malaria, while others with similar exposure remain well or develop mild illness. We are collaborating with engineers to develop new diagnostics for malaria and are taking novel approaches to identifying antibody responses that protect pregnant women and young children from malaria, and block malaria transmission to mosquitoes. 
 


Rogerson Group Current Projects