Project: Understanding immunodominance hierarchies of CD4 T follicular helper cells
CD4+ T follicular helper (Tfh) cells in lymph nodes are critical to the generation of effective neutralising antibody responses to infection and vaccination. Using our well developmed mouse models of prototype vaccines against influenza and SARS-CoV-2, this project will seek to underestand how prominent or subdominant CD4 T cell responses contribute to germinal centre development and elicitation of high quality antibody responses.
The Juno group is interested in the biogenesis of CD4 T follicular helper cells and their capacity to promote high quality antibody responses following infection or vaccination. Our major focus is immunity to viral infections such as influenza, SARS-CoV-2 and HIV. The lab uses a combination of human clinical samples and pre-clinical animal models to understand the phenotypic and functional characteristics of diverse CD4 T cell populations.