The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: Understanding gene regulation in Staphylococcus aureus

Stinear Group

Two component systems (TCS) enable bacteria to respond rapidly to the host environment. Among the 16 TCS in Staphylococcus aureus, only WalKR is essential, with clinical treatment failure linked to mutations within WalKR (leads to vancomycin resistance). Our laboratory has been investigating the molecular mechanism of WalKR function through the application of next generation DNA sequencing technologies such as RNAseq, ChIPseq, TNseq targeted mutagenesis and suppressor mutant screens. This project will apply the above techniques to determine the molecular basis of WalKR essentiality.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Tim Stinear

Project Co-supervisor

Dr Ian Monk

Project availability
Master of Biomedical Science

Stinear Group

3 vacancies

Antimicrobial Resistance
Bacterial and Parasitic Infections
Cross Cutting Disciplines
Computational Science and Genomics

The Stinear group study bacteria that can infect humans and cause disease and we study human immune responses to those bacteria. We make mutants.  We uncover molecular mechanisms of pathogenesis. We discover new antibiotics. We make vaccines. We create new diagnostic tests. We track disease outbreaks, . We sequence genomes and we expose dodgy science. Our research usually involves close collaboration with public health laboratories and with major hospitals  so that our research can be rapidly implemented and used to benefit society.

Stinear Group Current Projects