Project: Understanding essential gene regulation in Staphylococcus aureus
Two component systems (TCS) enable bacteria to respond rapidly to the host environment. Among the 16 TCS in Staphylococcus aureus, only WalKR is essential, with clinical treatment failure linked to mutations within WalKR (leads to vancomycin resistance). Our laboratory has been investigating the molecular mechanism of WalKR function through the application of next generation DNA sequencing technologies such as RNAseq, ChIPseq, TNseq targeted mutagenesis and suppressor mutant screens. This project will apply the above techniques to determine the molecular basis of WalKR essentiality.
The Stinear group is full of fun-loving microbiologists who make mutants, uncover molecular mechanisms of pathogenesis, discover new antibiotics, make vaccines, create new diagnostic tests, track disease outbreaks, sequence bacterial genomes and expose dodgy science. Our research aims to understand bacterial pathogens in greater detail so that we can develop tools to detect, inhibit or control them. We collaborate with major hospitals and public health labs so that our research can be rapidly implemented and used to benefit society.
Stinear Group Current Projects
PhD/MPhil, Master of Biomedical Science, Honours