Project: Understanding essential gene regulation in Staphylococcus aureus
Stinear Group
Two component systems (TCS) enable bacteria to respond rapidly to the host environment. Among the 16 TCS in Staphylococcus aureus, only WalKR is essential, with clinical treatment failure linked to mutations within WalKR (leads to vancomycin resistance). Our laboratory has been investigating the molecular mechanism of WalKR function through the application of next generation DNA sequencing technologies such as RNAseq, ChIPseq, TNseq targeted mutagenesis and suppressor mutant screens. This project will apply the above techniques to determine the molecular basis of WalKR essentiality.
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Stinear Group
3 vacancies
The Stinear group study bacteria that can infect humans and cause disease and we study human immune responses to those bacteria. We make mutants. We uncover molecular mechanisms of pathogenesis. We discover new antibiotics. We make vaccines. We create new diagnostic tests. We track disease outbreaks, . We sequence genomes and we expose dodgy science. Our research usually involves close collaboration with public health laboratories and with major hospitals so that our research can be rapidly implemented and used to benefit society.
Stinear Group Current Projects
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Understanding essential gene regulation in Staphylococcus aureus
PhD/MPhil, Master of Biomedical Science, Honours
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Impact of adenine methylation in unstable small colony variants of Staphylococcus aureus
Master of Biomedical Science, Honours
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Finding new antibiotics against Methicillin resistant Staphylococcus aureus
PhD/MPhil, Master of Biomedical Science, Honours
Research degrees at the Doherty Institute are administered by the University of Melbourne.