Project: Translational control during norovirus infection
This project will aim to identify key host and viral proteis that modulate the cellular translational machinery to facilitate virus replication. The project will explore molecular and cellular virology to decipher how norovirus is able to control the cells that in infects and to determine how this control can lead to cell death and virus release. The major aim is to provide advanced understanding of the virus replication cycle but to also identfy potential drug targets for antiviral therapy.
The Mackenzie Group investigates the intracellular replication of flaviviruses and noroviruses to understand how replication influences cellular functions and immune dysfunction. In particular, the influences viral replication imparts on metabolic and stress pathways that ultimately lead to immune regulation and dysfunction. We aim to use this knowledge to develop prevention and treatment options against these highly pathogenic viruses.