The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Towards precision biotherapeutics for combating multidrug resistance superbugs

Howden Group

The gastrointestinal microbiome plays an important role in blocking the acquisition of multidrug resistant superbugs in the gut. The identity of the commensal species involved and the mechanisms they employ to inhibit these superbugs and prevent gut colonisation remain unclear.  Using a multi-omics approach coupled with molecular microbiology and murine gut colonisation models, this project will define the commensal species involved in colonisation resistance and determine how these species inhibit hospital superbugs within the gut. This knowledge will lead to the development of precision biotherapeutics that can be used to combat multidrug resistant hospital superbugs.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Glen Carter

Project Co-supervisor

Professor Benjamin Howden

Project availability
PhD/MPhil
Master of Biomedical Science

Howden Group

danielle.ingle@unimelb.edu.au

3 vacancies

Themes
Antimicrobial Resistance and Healthcare Associated Infections
Host Pathogens Interactions
Cross Cutting Disciplines
Epidemiology
Global Health
Indigenous Health

Research Projects 2019 | 19 The Howden group is embedded in the state public health laboratory - the Microbiological Diagnostic Unit Public Health Laboratory (MDU PHL) - with expertise in pathogen genomics and antimicrobial resistance, including functional genomics technologies and models of disease. We complement these molecular biology studies with epidemiological and clinical studies to address a broad range of issues related to invasive bacterial diseases in humans, especially those caused by staphylococci, enterococci and other antimicrobial-resistant species (CPE). Working closely with scientists in the MDU PHL, we investigate the epidemiology, evolution and spread of bacterial pathogens of public health significance such as Neisseria gonorrhoea, Listeria monocytogenes, Legionella spp. and Salmonella spp.