Project: The role of the prion protein in cancer
The expression of the prion protein has been observed to both promote and suppress the hallmarks of cancer including cell proliferation, survirval and invasion. To better understand the role of prion protein in cancer development this project will use molecular biology approaches to delete the prion protein gene (CRISPR) from colorectal cancer and glioblatoma cells and modulating prion protein expression. The effect of altered prion protein expression will then by anlysed using proliferation, survival and invasion assays. This project will involve molecular and cellular biology methods.
The focus of the Lawson lab is disease affecting the brian and gut. Our research focus is on neurological disease, infectious disease and cancers.