The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: The role of growth factor immunosurveillance in human cancers

Barrow group

Growth factor surveillance is a new mode of cancer immunosurveillance in which the immune system responds to growth factors overexpressed by cancer cells. However, definitive proof that growth factor surveillance plays a role in immune responses to human cancers remains to be determined. Our transcriptional analysis has implicated natural killer (NK) cell recognition of platelet-derived growth factor (PDGF)-D in the control of GBM. In collaboration with the Mantamadiotis group, the Barrow group is developing novel immunohistochemical methods to assess the role of NK cells and PDGF-D in overall survival of glioma patients in addition to other cancers that express PDGF-D.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Alexander David Barrow

Project Co-supervisor

Dr Theo Mantamadiotis

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Barrow group

[email protected]

3 vacancies

Themes
Immunology
Viral Infectious Diseases
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research
Translational and Clinical Research

The Barrow group is interested in innate immune recognition programs, in particular a new immunological recognition strategy termed ‘growth factor surveillance’. Growth factors (GFs) are over-expressed by cancer cells to promote tumour growth. We first showed that the immune system evolved activating receptors to sense aberrant GF expression by cancers. The Barrow group’s goal is to understand how the immune system recognises GF expression by tumours with the ultimate aim of exploiting these pathways for cancer immunotherapy and the development of new cancer immunotherapies.


Barrow group Current Projects