The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: The gut microbiota and antimicrobial resistance

Howden Group

The gut microbiota plays an important role in susceptibility to colonisation (and infection) with antimicrobial resistant pathogens. This study will utilise high-throughput sequencing, metagenomic analyses and culturomics to interrogate microbial population determinants of susceptibility to antimicrobial resistant pathogens (vancomycin-resistant Enterococci and carbapenem-resistant Klebsiella spp.). The study will utilise murine models of gut colonisation, complemented with samples from hospitalised patients. The expected outcomes from this study include developing skills in laboratory-based and bioinformatic techniques in microbiome and antimicrobial resistance studies. 

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Benjamin Howden, Dr Glen Carter 

Project Co-supervisor

Professor Tim Stinear, Dr Andre Mu 

Project availability
Master of Biomedical Science

Howden Group

[email protected]

3 vacancies

Antimicrobial Resistance and Healthcare Associated Infections
Host Pathogens Interactions
Cross Cutting Disciplines
Global Health
Indigenous Health

Research Projects 2019 | 19 The Howden group is embedded in the state public health laboratory - the Microbiological Diagnostic Unit Public Health Laboratory (MDU PHL) - with expertise in pathogen genomics and antimicrobial resistance, including functional genomics technologies and models of disease. We complement these molecular biology studies with epidemiological and clinical studies to address a broad range of issues related to invasive bacterial diseases in humans, especially those caused by staphylococci, enterococci and other antimicrobial-resistant species (CPE). Working closely with scientists in the MDU PHL, we investigate the epidemiology, evolution and spread of bacterial pathogens of public health significance such as Neisseria gonorrhoea, Listeria monocytogenes, Legionella spp. and Salmonella spp. 

Howden Group Current Projects