The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: Targeting stem-like T cell niches to treat chronic infections

Mueller Group

Chronic viral infections and cancer lead to dysfunctional CD8 T cells, characterised by high expression of inhibitory molecules, such as PD-1. Targeting PD-1 in immunotherapy has been successful in improving outcomes in cancer, but there is a need to better understand the mechanisms that regulate CD8 T cell responses during chronic infections to improve immunotherapies and restore exhausted T cells. A newly described subset of CD8 T cells with stem-like features reside in T cell zones of the lymphoid organs during chronic infection and are the critical target if anti-PD-1 immunotherapy. This project will investigate new ways to improve treatments for chronic infections by targeting stem-like T cell niches. We will use newly generated mouse models that target lymphoid stromal cells during chronic virus infection, checkpoint blockade, flow cytometry and confocal microscopy.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Yannick Alexandre

Project Co-supervisor

Professor Scott Mueller

Project availability
Master of Biomedical Science

Mueller Group

5 vacancies

Viral Infectious Diseases
Cross Cutting Disciplines
Discovery Research

Research in the Mueller group is focused on examining immune responses and nervous system interactions during acute and chronic viral infections and in cancer. We are seeking a fundamental understanding of biology and new treatments for disease. We are using state-of-the-art methods, including advanced microscopy, spectral flow cytometry, single cell sequencing and bioinformatics.

Mueller Group Current Projects