Project: Role of suppressor of cytokine signalling proteins in viral encephalitis
Fazakerley Group
The suppressor of cytokine signalling (SOCS) proteins are key negative regulators of the JAK-STAT pathway and are responsible for controlling cytokine networks involved in immune response and inflammation. SOCS are expressed in the central nervous system (CNS) and have the potential to modulate immune responses in the brain. We have recently shown that SOCS4- and SOCS5-deficient mice have different susceptibility phenotypes to an alphavirus infection, that virus RNA persists in the brain, and that infectious virus can be reactivated following immunosuppression. This project aims to explore the role of SOCS4 or SOCS5 during SFV induced encephalitis in a mouse model.
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Fazakerley Group
3 vacancies
The Fazakerley group’s main interest is in the pathogenesis of infections caused by RNA viruses, in particular vector-borne (arbovirus) alphaviruses infections of the central nervous system and insect vectors. Our main focus is to dissect the immune mechanisms during viral encephalitis and virus persistence in the central nervous system. We also investigate the arthropod responses to alphaviruses and study their transmission in mosquito vectors.
Fazakerley Group Current Projects
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Role of suppressor of cytokine signalling proteins in viral encephalitis
PhD/MPhil, Master of Biomedical Science, Honours
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Age-dependent susceptibility of neurons to RNA virus infection
PhD/MPhil, Master of Biomedical Science, Honours
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Vertical transmission of Ross River virus in mosquito vectors
PhD/MPhil, Master of Biomedical Science, Honours
Research degrees at the Doherty Institute are administered by the University of Melbourne.