The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Role of O-linked glycosylation system across the Burkholderia genus

Scott group

Protein glycosylation, the chemical addition of sugars to proteins, is an important but poorly understood aspect of bacterial physiology. Within the Burkholderia genus, we have discovered a highly conserved O-linked glycosylation system. The conservation of this system across pathogenic and non-pathogenic species suggests that glycosylation plays a far more fundamental role in the physiology of Bukholderia than previously thought. The goal of this project is to understand the role and diversity of glycosylation in Bukholderia. By studying glycosylation within Burkholderia we aim to gain a fundamental understanding of this biological processes and how it contributes to bacterial survival.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Nichollas Scott

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Scott group

[email protected]

2 vacancies

Themes
Antimicrobial Resistance and Healthcare Associated Infections
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research

The Scott group focuses on the identification and characterisation microbial mediate protein glycosylation. This post translational modification allows pathogens to radically alter the function of proteins both within them, and their hosts. Within a range of pathogens such as malaria and Burkholderia, microbial protein glycosylation is used for both defensive and offensive processes, enabling pathogens to fortify themselves against the host immune response or to disarm the host’s ability to resist infection. Using mass spectrometry-based approaches, the Scott group seeks to develop methodologies to identify and track microbial glycosylation events to understand how microbes remodel their proteome and that of the hosts. 


Scott group Current Projects