The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: Reprogramming Immunity by Engineering B cells

Wheatley Group

B cells are a central arm of the adaptive immune system designed to recognise foreign antigens and make antibodies. Using modern Crispr/Cas nucleic acid editing tools, we will alter the specificity of the B cell receptor to drive high affinity recognition of viral antigens. Such cells will be critical tools enabling the further characterisation of B cell differentiation and selection using a range of in vitro and in vivo models of viral infection or vaccination.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Adam Wheatley

Project Co-supervisor

Dr Hyon-Xhi Tan

Project availability

Wheatley Group

3 vacancies

Viral Infectious Diseases
Cross Cutting Disciplines
Discovery Research

The Wheatley group is interested in factors that program broad and durable humoural immunity against infectious pathogens  such as SARS-CoV2 and influenza. Our research involves immunological charactersiaton of B cells and antibodies, development of assays and tools to study antiviral immunity, novel vaccine design and the development of monoclonal antibodies to treat or prevent infections.