Project: Reprogramming Immunity by Engineering B cells
Wheatley Group
B cells are a central arm of the adaptive immune system designed to recognise foreign antigens and make antibodies. Using modern Crispr/Cas nucleic acid editing tools, we will alter the specificity of the B cell receptor to drive high affinity recognition of viral antigens. Such cells will be critical tools enabling the further characterisation of B cell differentiation and selection using a range of in vitro and in vivo models of viral infection or vaccination.
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Wheatley Group
3 vacancies
The Wheatley group is interested in factors that program broad and durable humoural immunity against infectious pathogens such as SARS-CoV2 and influenza. Our research involves immunological charactersiaton of B cells and antibodies, development of assays and tools to study antiviral immunity, novel vaccine design and the development of monoclonal antibodies to treat or prevent infections.