Project: Regeneration of lymphoid tissues
In the wake of infectious disease, or following lymph node removal, there is little evidence that lymph nodes can regenerate. Lymphoid organs are constructed from heterogeneous subsets of stromal cells that control immune cell survival and immune responses. Using new transgenic mice, this project will examine how lymphoid tissues expand and respond to infection, and how destruction of the tissue environment is regenerated by stromal cells. This will reveal new avenues to repair damage to lymphoid tissues and support immunity. Advanced multi-colour imaging, flow cytometry and molecular techniques will be used to address these questions.
Research in the Mueller group is focused on examining immune responses to acute and chronic viral infections and to tumours. We are using state-of-the-art methods, including intravital 2-photon microscopy to visualise immune cells and pathogens in real time. We are examining how T cells are activated and protect against infections, the induction of immune memory and tissue-resident memory T cells, and the role of stromal cells and nerves in tissues for the design of new vaccines and therapeutics.