Project: Regeneration of lymphoid tissues
Using new transgenic mice, this project will examine how lymphoid tissues expand and respond to infection and support memory T cell responses. We will examine how destruction of the tissue environment is regenerated by stromal cells.
Research in the Mueller group is focused on examining immune responses to acute and chronic viral infections and to tumours. We are using state-of-the-art methods, including intravital 2-photon microscopy to visualise immune cells and pathogens in real time. We are examining how T cells are activated and protect against infections, the induction of immune memory and tissue-resident memory T cells, and the role of stromal cells and nerves in tissues for the design of new vaccines and therapeutics.