The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Protective capacity of malaria-specific liver-tissue-resident memory T cells

Heath Group

We have developed a glycolipid-peptide conjugate vaccine that provides sterile immunity against malaria. Protection in this model is absolutely dependent on malaria-specific tissue-resident CD8 T cells, but how these cells provide protection is not clear. This project will investigate which cell population in the liver re-activates malaria-specific tissue-resident memory T cells after challenge, and how the phenotype and behaviour of these cells changes after challenge. This project will use animal models in combination with advanced immunological techniques including flow cytometry and intravital imaging.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Lauren Holz

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Heath Group

[email protected]

3 vacancies

Themes
Host Pathogens Interactions
Immunology
Cross Cutting Disciplines
Discovery Research

The Heath group is interested in the immune response to pathogens, particularly to malaria, which is still a major cause of mortality worldwide. We study T cell responses with the aim of improving vaccine strategies and focus on T cell responses in the skin, the liver and lymphoid organs including the spleen. Our lab recently discovered a population of resident memory T cells within the liver that are capable of protecting against malaria infection. These and other cells are currently being studied. 


Heath Group Current Projects