The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Programming gamma delta T cells for HIV immunotherapy

Kent group

Gamma delta T cells are an unconventional T cell subset with cytotoxic activity. These cells are currently being tested in human clinical trials for their ability to kill cancer cells, but less is known about their utility in treating infectious diseases. Preliminary studies from our lab have identified gamma delta T cell subsets with different cytotoxic potential. This project will focus on identifying methods to expand gamma delta T cell populations that can kill HIV-infected T cells in vitro.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Stephen Kent

Project Co-supervisor

Dr Jennifer Juno

Project availability
Master of Biomedical Science
Honours

Kent group

[email protected]

3 vacancies

Themes
Immunology
Cross Cutting Disciplines

Research Projects 2019 | 25 The Kent group has an interest in understanding how the immune response can be harnessed in the control of infectious pathogens including HIV, Mycobacterium tuberculosis and influenza. This includes understanding non-conventional T cells and how they are impacted by HIV infection despite the fact that they are not target cells for HIV replication. We use animal models to investigate ways to manipulate these cells and to understand how they are regulated during viral infection. We also examine how antibodies can instruct the innate immune system to attack invading pathogens through their Fc regions. Our research aims to understand the mechanisms behind these antibodies in order to guide the development of more effective antibody therapeutics and vaccines. 


Kent group Current Projects