The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Preventing infections of the highly puke-ogenic virus - norovirus

Mackenzie Group

Norovirus infections result in a highly acute disease with symptoms that include explosive diarrhea and projectile vomiting. It is an infection that affects 700 million people each year and you are likely to get four to five infections over your lifetime. Yet there is no treatment or prevention options against this significant pathogen, as efforts have been hampered by the inability to effectively cultivate the virus in laboratory conditions. In this project we aim to utilise a vaccine development platform to generate virus-like particles of norovirus and determine their effectiveness in priming and providing a protective immune response to infection. The project will involve the design and production of the virus-like particles to be used in vaccination regimes. Subsequently, the immune response generated to these particles will be assessed. We will also generate virus-like particles to the related mouse norovirus, providing us with an effective model to assess neutralisation and immune correlates, and a tool for us to isolate reactive memory B cells for antibody isolation. 

Contact project supervisor for further
information and application enquiries

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Mackenzie Group

[email protected]

1 vacancies

Themes
Host Pathogens Interactions
Immunology
Viral Infectious Diseases
Cross Cutting Disciplines
Discovery Research

The Mackenzie group investigates how viruses interact with the cells they infect. In particular the molecular and cellular processes that are manipulated by flaviviruses (dengue, Zika and West Nile viruses) and noroviruses for their own gain. We aim to understand how the intracellular events of virus replication result in innate immune evasion and ultimately how the consequences of infection result in a diseased state. Answering these questions will guide and inform us of areas for antiviral therapeutic development.


Mackenzie Group Current Projects