The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Population genomics of endemic Streptococcus pyogenes

Davies Group

Streptococcus pyogenes is one of the leading infectious disease agents in the world. The disease burden is alarmingly high within the Top End of Australia where the epidemiology of infection contrasts that of other geographical regions. Through linking genomics with epidemiology, we aim to examine the evolutionary relationship between disease causing Streptococcus pyogenes clones within remote communities of Australia. Furthermore, we will apply statistical genetic models to identify genetic signatures associated with different disease stats and/or tissue tropism. Unlocking these mysteries is key to informing public health intervention strategies including the development of informed vaccine programs within disease endemic regions. 

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Mark Davies

Project Co-supervisor

Associate Professor Steven Tong

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Davies Group

[email protected]

3 vacancies

Themes
Antimicrobial Resistance and Healthcare Associated Infections
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research
Genomics
Indigenous Health
Public Health

The Davies group aims to apply genome sequencing methodologies and bioinformatics approaches to understand the evolution and transmission of bacterial pathogens. This knowledge can help facilitate a global understanding of pathogen evolution, in addition to informing public health intervention to reduce the disease burden associated with bacterial pathogens. Current projects address key research questions such as: is there a genetic difference between strains causing different disease manifestations? What is driving the emergence and dissemination of bacterial pathogens? Do host immune factors govern disease severity? Our research closely aligns with key international collaborators including the Wellcome Trust Sanger Institute in the United Kingdom.