The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Phylodynamic modelling of outbreaks of multidrug resistant enteric pathogens

Howden Group

Enteric bacterial pathogens, including Shigella species and serovars of Salmonella enterica, represent serious public health threats. The emergence of widespread multidrug resistance to standard antimicrobial therapy has resulted in changing outbreak dynamics. This computational microbiology project will work at the interface of public health microbiology. This project will integrate large bacterial genomic datasets with epidemiological data and infectious disease modelling. These approaches have been successfully used for viral outbreaks, but remain underutilised for bacterial pathogens. The application of these phylodynamic modelling will help to better understand the outbreak dynamics of enteric bacterial pathogens.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Danielle Ingle

Project Co-supervisor

Dr Sebastian Duchene
Professor Ben Howden

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Howden Group

danielle.ingle@unimelb.edu.au

3 vacancies

Themes
Antimicrobial Resistance and Healthcare Associated Infections
Host Pathogens Interactions
Cross Cutting Disciplines
Epidemiology
Global Health
Indigenous Health

Research Projects 2019 | 19 The Howden group is embedded in the state public health laboratory - the Microbiological Diagnostic Unit Public Health Laboratory (MDU PHL) - with expertise in pathogen genomics and antimicrobial resistance, including functional genomics technologies and models of disease. We complement these molecular biology studies with epidemiological and clinical studies to address a broad range of issues related to invasive bacterial diseases in humans, especially those caused by staphylococci, enterococci and other antimicrobial-resistant species (CPE). Working closely with scientists in the MDU PHL, we investigate the epidemiology, evolution and spread of bacterial pathogens of public health significance such as Neisseria gonorrhoea, Listeria monocytogenes, Legionella spp. and Salmonella spp.