Project: Optimising cohorts for HIV cure interventions: the role of very high CD4 T-cell counts (HI-ART study)
Preliminary work has identified that people living with HIV who start treatment with very high CD4 counts have lower HIV DNA levels, a measure of the latent reservoir. This pilot project will add to this data, looking at 2 cohorts of people with high CD4 counts on HIV treatment, and comparing them to controls. The student will learn and apply a range of laboratory techniques and analysis of virology assays, immunology assays and exploratory assays including measures of cell proliferation such as pSTAT 5. The student will have the opportunity to work with a laboratory supervisor and a clinical supervisor, with the option of visiting clinical sites to understand how and from who samples are obtained.
The main focus of the Lewin group is to understand why HIV infection persists on antiretroviral therapy and to develop new strategies to eliminate latent HIV. We do this through laboratory based virology and immunology studies, analysis of patient samples and interventional studies aimed at disrupting and/or eliminating HIV latency.