The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: Novel master-regulators of B-cell biology

Mackay, Fabienne Group

We generated CRISPR knock-out mouse lines in which putative B-cell regulating genes are specifically deleted. Changes in the B-cell repertoire are detectable using flow cytometry and immunofluorescence techniques. This project aims to understand more about the function and mechanism of these novel proteins and determine how they control fundamental B-cell biology.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Fabienne Mackay

Project Co-supervisor

Dr Catherine Kennedy, Dr William Figgett

Project availability
Master of Biomedical Science

Mackay, Fabienne Group

[email protected]

2 vacancies

Cross Cutting Disciplines
Public Health
Translational and Clinical Research

Professor Mackay’s group has an interest in autoimmune diseases and mechanisms leading to loss of immune tolerance, in particular that of B-lymphocytes. Professor Mackay has spent years studying a cytokine from the tumour necrosis factor superfamily named BAFF/ BLyS and demonstrated the role of this factor in B cell survival. Excess B cell activating factor (BAFF) leads to autoimmunity in mice and is associated with human autoimmunity, in particular Systemic Lupus Erythematosus (SLE) and Sjögren’s syndrome. Belimumab, a therapeutic BAFF-blocking antibody has been approved for use in SLE in the clinic in March 2011. This clinical outcome validates over ten years of Professor Mackay’s work on BAFF. 

Mackay, Fabienne Group Current Projects